Investigation of the porphyrin excretion patterns of a series of patients with symptomatic cutaneous hepatic porphyria has shown that They excrete at least two previously undescriptionbed tetracarboxylic porphyrins, one of which contains an hydroxyl group, in their faeces.
Urinary porphyrin patterns in inherited and acquired (""symptomatic"") hepatic porphyrias are of diagnostic significance and reflect the activity of the enzymes involved in the biosynthetic chain between uroporphyrinogen and protoporphyrin.
Improved immunofluorescence techniques, using epiilluminiation and blue narrow band excitation showed the presence of immunoglobulins, complement and fibrinogen in the thickened vessel walls of the upper dermis, which are probably caused by damage to the vessel walls by light.
Ferrokinetic studies were undertaken in 40 normal subjects and 7 subjects with symptomatic porphyria in an attempt to detect a constant abnormality in the metabolic disposition of injected radioactive iron. No such abnormality was found.