Serum immunoglobulin levels in Black children were estimated and the results analysed in 13 age ranges, from birth up to 15 years of age. Samples from children whose serum immunoglobulins were unlikely to be affected by their clinical condition were chosen for the analysis.
Somatostatin, a growth hormone release-inhibiting factor, isolated originally from the hypothalamus, has been shown to have widespread effects on brain and endocrine and exocrine pancreatic and gut function.
Nine children with the Cornelia de Lange syndrome have been examined and investigated. Prominent among the clinically important features are retarded physical and mental development, limb malformation and limited life expectancy.