oa South African Medical Journal - Halogenated analgesics and hepatotoxicity

Volume 59, Issue 12
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



The otherwise safe and useful anaesthetic halothane has been suspected of producing the occasional complication of hepatic necrosis, ascribed either to a drug allergy or to biotransformation to reactive intermediates. Several characteristics, such as middle age, obesity and multiple administrations of the anaesthetic, seem to put the patient at higher risk.

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