oa South African Medical Journal - Administration of depolarizing muscle relaxants after non-depolarizer reversal: when is it safe?
|Article Title||Administration of depolarizing muscle relaxants after non-depolarizer reversal: when is it safe?|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Department of Anaesthesia, University of Stellenbosch, Parowvallei, CP|
|Publication Date||Apr 1982|
|Pages||583 - 584|
|Keyword(s)||Anaesthesiology, Depolarising muscle relaxants, Neostigmine and Non-depolariser reversal|
In the light of studies on the duration of action and pharmacokinetics of intravenous neostigmine, it is recommended that, depending upon the dosage administered! at least 1 hour should elapse before a depolarizer can safely be given after neuromuscular reversal with neostigmine, and at least 90 - 120 minutes after reversal with physostigmine.
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