oa Molecular Diagnosis and Vaccines - Role of human herpesvirus 7 in pityriasis rosea



Pityriasis rosea (PR) was long thought to be due to an infectious agent, however, this agent is not known. Recently, the association between PR and human herpesvirus type 7 (HHV7) has been a matter of debate. The work was initiated to investigate if there is an association between HHV-7 and PR with its clinical variants. Thirty patients with PR (17 classical type, 7 without herald patch, and 6 inverse PR), 15 matched dermatological controls (8 tinea corporis and 7 psoriasis), and 15 apparently healthy controls were examined for HHV-7 DNA in plasma by nested polymerase chain reaction (nPCR). Seventeen (56.7%) of PR patients were positive for HHV-7 in plasma, while none of the controls (dermatological and healthy) were positive, (P<0.001). Out of the 17 classic PR patients15 (88.2%), and 2 out of the 7 with secondary rash only (28.6%) were HHV-7 DNA positive, while all inverse PR patients were negative (P< 0.001) in conclusion, PR, especially the classic type, is associated with active replication of HHV-7, which could by primary infection or reactivation of latent infection.


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