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oa Molecular Diagnosis and Vaccines - Role of human herpesvirus 7 in pityriasis rosea

 

Abstract

Pityriasis rosea (PR) was long thought to be due to an infectious agent, however, this agent is not known. Recently, the association between PR and human herpesvirus type 7 (HHV7) has been a matter of debate. The work was initiated to investigate if there is an association between HHV-7 and PR with its clinical variants. Thirty patients with PR (17 classical type, 7 without herald patch, and 6 inverse PR), 15 matched dermatological controls (8 tinea corporis and 7 psoriasis), and 15 apparently healthy controls were examined for HHV-7 DNA in plasma by nested polymerase chain reaction (nPCR). Seventeen (56.7%) of PR patients were positive for HHV-7 in plasma, while none of the controls (dermatological and healthy) were positive, (P<0.001). Out of the 17 classic PR patients15 (88.2%), and 2 out of the 7 with secondary rash only (28.6%) were HHV-7 DNA positive, while all inverse PR patients were negative (P< 0.001) in conclusion, PR, especially the classic type, is associated with active replication of HHV-7, which could by primary infection or reactivation of latent infection.

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/content/mdv/1/1/AJA16872010_10
2003-01-01
2016-12-02
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