n South African Gastroenterology Review - The irritable bowel syndrome : clinical review

Volume 1, Issue 1
  • ISSN : 1812-1659



Extracted from text ... CLINICAL REVIEW The South African Gastroenterology Review - August 2003 4 The Irritable Bowel Syndrome cepted mechanism thought to be responsible for IBS. Rectal balloon distension studies in IBS patients demonstrate lower sensory thresholds for pain and discomfort when compared to asymptomatic controls.2 What is not clear is at what level this heightened visceral perception occurs. Most likely it represents recruitment of silent nociceptors in the gut wall in response to either physiological events (intra-luminal contents) or pathological triggers (infection or inflammation). On the other hand visceral hypersensitivity may result from enhanced dorsal horn excitability at the level of ..

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