n South African Gastroenterology Review - The management of hepatitis C virus infection in difficult-to-treat populations : patients with end stage renal disease, HIV infected patients and children : review

Volume 10, Issue 1
  • ISSN : 1812-1659



Approximately 175 million people are infected with hepatitis C (HCV) worldwide, whilst ∼3-4 million people are newly infected annually. In South Africa the prevalence is thought to be low in the general population, although increases in acute infections are being reported in some risk groups eg. men who have sex with men. This infection is treatable and curable, but the treatment has many side effects and is expensive to administer in resource poor settings. Standard therapy has been pegulated interferon and ribavirin (PEG+RBN). Over the last year new orally active drugs called Directly Acting Agents (DAAs) have become available.

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