n South African Gastroenterology Review - Predicting poor-outcome Crohn's diseases : review

Volume 11, Issue 2
  • ISSN : 1812-1659



Crohn's disease (CD) and ulcerative colitis (UC) are the two commonest forms of inflammatory bowel disease (IBD). UC is limited to the colon and is characterised by continuous superficial inflammation. In contrast, CD may affect any part of the GIT in a discontinuous fashion from mouth to anus, most commonly involving the terminal ileum. CD is characterised histologically by non-necrotising granulomatous inflammation that is transmural in nature. CD is a life-long disorder which may manifest at any time from early childhood to late adulthood. Typically, however, CD is diagnosed in the late teens and early twenties, with over 80% before the age of 40 years.

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