n South African Gastroenterology Review - Effect of tegaserod on quality of life and symptom relief in women with irritable bowel syndrome with constipation in South Africa : research

Volume 4, Issue 1
  • ISSN : 1812-1659



&lt;I&gt;Background:&lt;/I&gt; Tegaserod is a promotility agent with proven efficacy and safety in patients with irritable bowel syndrome with constipation (IBS-C). &lt;br&gt;&lt;I&gt;AIM:&lt;/I&gt; Assess tegaserod's effect on quality of life (QOL) and symptom relief in South African patients. &lt;br&gt;&lt;I&gt;Methods:&lt;/I&gt; Women >18 years old meeting Rome II criteria for IBS-C were enrolled in a prospective, open-label, multi-center study in South Africa, consisting of a 2-week treatment-free baseline period, followed by a 4-week tegaserod 6 mg b.i.d. treatment period. QOL was assessed using the IBS-QOL questionnaire, at -2 weeks, baseline and 4 weeks; symptom relief was evaluated with daily diaries and weekly assessments of overall symptom relief. &lt;br&gt;&lt;I&gt;Results:&lt;/I&gt; Of the 242 women enrolled, 210 completed the study visits and questionnaires. Compared with baseline, tegaserod significantly improved overall QOL and domains at Week 4 (p values<0.001). Overall symptom relief was reported by 68.7% of patients. At Week 4 tegaserod significantly improved number of bowel movements, stool form, straining, sense of incomplete evacuation, abdominal pain and bloating (p values<0.001). Significant improvements were observed at Week 1 and sustained throughout the study. <br><I>Conclusions:</I> Tegaserod significantly improves QOL and relieves the multiple symptoms associated with IBS-C. Symptom improvement was observed early and was sustained through study end.

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