n South African Gastroenterology Review - SAGES Guidelines Prevention and management of gastro-oesophageal varices and variceal haemorrhage in cirrhosis : guidelines

Volume 6, Issue 1
  • ISSN : 1812-1659



Portal hypertension, the end stage of any chronic liver disease, is caused by (1) an increased resistance to blood flow due to (a) architectural distortion of the liver by fibrous tissue and regenerative nodules (b) active intra-hepatic vaso-constriction due to decreased endogenous production of NO (2) increased portal venous inflow due to splanchnic arteriolar vasodilatation and (3) insufficient portal de-compression through collaterals which offer greater resistance to flow than does the normal liver.

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