n South African Gastroenterology Review - Cell proliferation and oncogenesis : review

Volume 6, Issue 3
  • ISSN : 1812-1659



The restriction point (R point) occurs late in G1, but is a critical point where the cell would either pass into S phase and complete the cycle, arrest in the G1 phase or exit into a quiescent G0 phase. It is thought that mutations in the Rb gene, coding for the Rb protein, play a role in neoplastic progression.

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