n South African Gastroenterology Review - World Gastroenterology Organisation Practice Guideline - Hepatitis B September 2008 : guidelines
|Article Title||World Gastroenterology Organisation Practice Guideline - Hepatitis B September 2008 : guidelines|
|© Publisher:||In House Publications|
|Journal||South African Gastroenterology Review|
|Author||J. Heathcote, Z. Abbas, A. Alberti, Y. Benhamou, C. Chen, A. Elewaut, P. Ferenci, C. Hui, V. Isakov, H. Janssen, G. Lau, S. Lim, T. Okanoue, S. Ono-Nita, T. Piratvisuth, M. Rizzetto, I. Sollano, W. Spearman, C-T. Yeh, M. Yuen and J. Krabshuis|
|Publication Date||Mar 2009|
|Pages||18 - 28|
In summary, the outcome of HBV infection largely depends on the host-virus interaction, mediated by the adaptive immune response. The virus-specific T cell response is one of the key factors in the pathogenesis of HBV infection. Viral variants may influence the course and outcome of the disease. The effect of host factors in the progression of disease is underappreciated. Only very rarely (when there is profound immune suppression) does the hepatitis B virus become directly cytopathic.
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