n South African Gastroenterology Review - SAGES clinical practice guidelines on the use of intravenously administered proton pump inhibitors (PPI) : guidelines
|Article Title||SAGES clinical practice guidelines on the use of intravenously administered proton pump inhibitors (PPI) : guidelines|
|© Publisher:||In House Publications|
|Journal||South African Gastroenterology Review|
|Publication Date||Aug 2009|
Clinical situations in which intravenously administered PPI may be appropriate are
A meta-analysis of 21 randomised controlled trials evaluating proton pump inhibitors for bleeding ulcers (with or without endoscopic therapy) found a significant reduction in the risk of rebleeding (OR 0.40, 95 % CI 0.33 - 0.64) and the need for surgery (OR 0.59, 95 % CI 0.46 - 0.76) but no effect on mortality.
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