n South African Gastroenterology Review - SAGES clinical practice guidelines on the use of intravenously administered proton pump inhibitors (PPI) : guidelines




Clinical situations in which intravenously administered PPI may be appropriate are

  • Hypersecretory states.
  • Gastro-oesophageal reflux disease in patients unable to take by mouth or swallow.
  • Upper gastro-intestinal haemorrhage.

  • A meta-analysis of 21 randomised controlled trials evaluating proton pump inhibitors for bleeding ulcers (with or without endoscopic therapy) found a significant reduction in the risk of rebleeding (OR 0.40, 95 % CI 0.33 - 0.64) and the need for surgery (OR 0.59, 95 % CI 0.46 - 0.76) but no effect on mortality.


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