n South African Gastroenterology Review - Viral Hepatitis and HIV co-infection : review

Volume 9, Issue 1
  • ISSN : 1812-1659



Viral hepatitis and HIV are important global public health problems with enormous economic and social consequences. In Africa these epidemics converge, compounding the effect of each. Sub-Saharan Africa harbours 70% of the world's prevalence of HIV, and has a HBV population prevalence of <8%. About 20% of those living with HIV are co-infected with HCV, with the highest reported prevalence rates in Asia and Africa. As HIV therapy has increased longevity, liver disease has emerged as an important cause of morbidity and mortality in this group of patients. The risk of liver related death is higher among HIV/HBV or HIV/HCV co-infected individuals than among those infected with either virus alone. The impact of co-infection is not only on the rate of progression of liver disease, but also on other factors like drug interactions and drug side effects.

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