n South African Psychiatry Review - Membrane function alterations in erythrocytes from mood disorder patients : research article

Volume 6, Issue 1
  • ISSN : 1811-7805



Objectives : To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). <br>Design : Collection of blood samples from mood disorder patients and age-matched control volunteers. Preparation of erythrocyte membranes for the proposed studies. <br>Setting : Out patients / in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S.University of Baroda, Vadodara, Gujarat, India. <br>Subjects : Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). <br>Results : The most significant results were a duration dependent decrease in the TPL / CHL ratio (mole : mole), changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. <br>Conclusion : The results suggest that the altered lipid profiles and the TPL / CHL (mole : mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood disorders. <br>Abbreviations used : <br>ACh - Acetylcholinesterase; ACTI - Acetylthiocholineiodide; BChE - Butyrylcholinesterase; BCTI -Butyrylthiocholineiodide; CHL Cholesterol; DPH - 1,6-Diphenyl -1,3,5-hexatriene; DTNB - 5,5' - Dithiobis(2-nitrobenzoic acid); ETPZ.HCl - Ethopropazine hydrochloride; Lyso, Lysophospholipid; PA - Phosphatidic acid; PC - Phosphatidylcholine; PE - Phosphatidylethanolamine; PC - Phosphatidylinositol; PS - Phosphatidylserine; SPM - Sphingomyelin; SDS - Sodium dodecyl sulfate; TPL - Total phospholipid.

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