n South African Psychiatry Review - Antidepressant efficacy may be enhanced with dual reuptake inhibition : product news

Volume 9, Issue 1
  • ISSN : 1811-7805



Extracted from text ... South African Psychiatry Review ? February 2006 65 PRODUCT NEWS S Afr Psychiatry Rev 2006;9:65 The new dual reuptake inhibitors (SNRIs), such as duloxetine, display a balance between serotonin (5-HT) and noradrenaline (NA) selectivity. These new antidepressants may offer improvements in efficacy, in the same way that the SSRIs introduced improvements in tolerability over the TCAs (through reduced affinity for alpha 1, histamine H 1 and cholinergic receptors). Figure 1 It is likely that dual reuptake inhibition is able to cover more of the symptoms experienced with depression. This greater spectrum of effectiveness may result in more responders and ..

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