n African Journal of Psychiatry - Early response or nonresponse of schizophrenia symptoms to antipsychotic medication is a predictor of long-term outcome : product news

Volume 12, Issue 2
  • ISSN : 1994-8220



After prescribing antipsychotic medication, many clinicians will wait 4 to 8 weeks before deciding whether to maintain the current treatment or to change it if the patient displays a suboptimal clinical response. However, a recent meta-analysis of randomised clinical trials (RCTs) has demonstrated that this delay is unnecessary, because the greatest reduction of symptoms occurs during the first 2 weeks of therapy. Furthermore, post hoc analyses of RCTs have shown that nonresponse in the first 2 weeks after treatment initiation is a reliable predictor of subsequent nonresponse in patients with schizophrenia.

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