n African Journal of Psychiatry - Cognitive effects of Olanzapine treatment in schizophrenia : product news

Volume 13, Issue 1
  • ISSN : 1994-8220



As much as 85% of patients with schizophrenia have significant impairment in most domains of cognitive functioning. This impairment has been reported to be present shortly after recovery from the first period of psychosis and to persist. It is likely that it may precede the development of psychotic symptoms, becoming manifest, and contributing to the loss in function, during the prodromal period. The cognitive disturbance is slowly progressive in most patients, but a small proportion shows severe deterioration as the duration of illness increases. The degree of impairment in various domains of cognition differs in patients with schizophrenia, with some studies suggesting that the most severe cognitive impairments occur in measures of attention, verbal fluency, motor speed, and executive function. Moderate impairments in working memory, immediate memory span, and verbal learning and memory have been reported most frequently. All of these impairments are disproportionate to the mild intellectual decline demonstrated in patients with schizophrenia as a group.

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