n African Journal of Psychiatry - Efficacy and tolerability of duloxetinein elderly patients with generalized anxiety disorder : a pooled analysis of four randomized, double-blind, placebo-controlled studies : product news

Volume 13, Issue 2
  • ISSN : 1994-8220



Generalized anxiety disorder (GAD) is common in the elderly. Symptoms of GAD often develop earlier in life, but in a substantial number of elderly patients, GAD appears for the first time after age 60.The symptoms in elderly patients may include insomnia, hypervigilance, and difficulties with cognition, and may be confused for depression or dementia. Treating GAD or high-trait anxiety symptoms in the elderly is important because GAD can affect physical health and psychological health. These patients may be at a greater risk for mortality and suicide. Treating elderly patients can be difficult because they may have higher rates of polypharmacy, including benzodiazepine use. Furthermore, the efficacy and tolerability of medications in the elderly may differ from those in younger patients because of age-related changes in drug metabolism.

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