n African Journal of Psychiatry - Duloxetine as an SNRI treatment for generalized anxiety Disorder (GAD) : results from a placebo and active-controlled trial : product news

Volume 13, Issue 2
  • ISSN : 1994-8220



Characterized by persistent, difficult-to-control, chronic worry, GAD is a prominent anxiety disorder owing to its pervasiveness, chronicity, and functional impairment. The underlying neurobiology of GAD suggests involvement of several neurotransmitter systems, including serotonin, norepinephrine, and g-aminobutyric acid (GABA) transmission. In this context, the development of dual-reuptake inhibitors of serotonin and norepinephrine (SNRIs) has been particularly useful and promising for the treatment of GAD.

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