n African Journal of Psychiatry - Early symptom change and prediction of subsequent remission with olanzapine augmentation in divalproex-resistant bipolar mixed episodes : product news

Volume 13, Issue 3
  • ISSN : 1994-8220



Patients with bipolar I disorder mixed vs. pure manic episodes may have a more severe course of illness, with slower and less frequent remissions and higher rates of recurrence. Assessment of the prognostic value of early symptom response is of particular importance for this complex and common manifestation of bipolar I disorder. Effective treatment early in the course of illness is a critical component in the long-term management of bipolar I disorder and in achieving earlier and possibly more sustained remission. Interest in using early symptom improvement in both mood and psychotic disorders to predict remission is reflected in a number of analyses, particularly with respect to lack of early improvement as predictive of lack of eventual remission with pharmacotherapy

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