n African Journal of Psychiatry - A comparison between the efficacy of dydrogesterone and calcium plus vitamin D in improving women's general health : original article




The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effect of dydrogesterone and calcium plus vitamin D on young women's general health. One hundred and eighty students studying at Shiraz University were recruited. Students completed the General Health Questionnaires (GHQ-28) prior to participation. They were then randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of their menstrual cycle for 2 consecutive cycles, and to complete the same questionnaires during both the intervention cycles. The effects of dydrogesterone and calcium plus vitamin D on general health scores were similar during the first month of intervention (11.41±4.28, 12.23±3.76, respectively) (p>0.05) and both of them were more effective than placebo (16.69±3.28) (p<0.05). However, dydrogesterone was more effective than calcium plus vitamin D and placebo during the second month of intervention (4.33±2.69, 6.2±3.55, 14.39±3.45, respectively) (p<0.05). No significant differences between groups regarding drugs' side effects (p>0.05) were found. Both dydrogesterone and calcium D were more effective than placebo in promoting women's general health. Dydrogesterone was, however, more efficient than calcium plus vitamin D.


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