n African Journal of Psychiatry - Pseudophaeochromocytoma associated with Clozapine Therapy : a case report : scientific letter




Elevation of plasma noradrenaline levels has been reported as a consistent clinical effect of clozapine, due to its potent effect on α2-adrenergic receptors. The relationship between this elevation and clinical effectiveness remains inconclusive. Davidson et al concluded that the elevation was unrelated to clinical effectiveness. However, Breier et al reported a positive correlation between plasma noradrenaline elevation and clinical improvement in patients on clozapine treatment.


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