n African Journal of Psychiatry - Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder : product news
|Article Title||Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder : product news|
|© Publisher:||In House Publications|
|Journal||African Journal of Psychiatry|
|Affiliations||1 University of Toronto, Canada|
|Publication Date||Sep 2012|
Asenapine sublingual is a novel atypical antipsychotic approved in August 2009 for the acute treatment of schizophrenia, as well as for manic or mixed episodes as part of adult bipolar I disorder. Asenapine's in vitro profile is similar to other atypical antipsychotic agents insofar as there is higher affinity for serotonin 5-HT2A versus dopamine D2 receptors. Asenapine exhibits a unique effect on monoamine, histamine and muscarinic receptor affinities, as well as effects on NMDA and AMPA receptors.
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