n African Journal of Psychiatry - Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder : product news

Volume 15, Issue 5
  • ISSN : 1994-8220



Asenapine sublingual is a novel atypical antipsychotic approved in August 2009 for the acute treatment of schizophrenia, as well as for manic or mixed episodes as part of adult bipolar I disorder. Asenapine's in vitro profile is similar to other atypical antipsychotic agents insofar as there is higher affinity for serotonin 5-HT versus dopamine D receptors. Asenapine exhibits a unique effect on monoamine, histamine and muscarinic receptor affinities, as well as effects on NMDA and AMPA receptors.

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