n African Journal of Psychiatry - Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea : scientific letter

Volume 16, Issue 4
  • ISSN : 1994-8220



Sialorrhea is a common adverse effect of clozapine therapy, which may increase the risk of aspiration pneumonia, a potentially life threatening condition. M4 agonism, α2 antagonism and impaired deglutition have been hypothesised as probable underlying mechanisms. A few previous case reports have shown topical atropine, an antimuscarinic agent, to be effective in the management of clozapine induced sialorrhea (CIS). Informed consent was received for publication of the following case material.

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