n African Journal of Psychiatry - Clozapine-induced recurrent and transient parotid gland swelling : scientific letter

Volume 16, Issue 4
  • ISSN : 1994-8220



Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.

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