n African Journal of Psychiatry - Sodium valproate for the treatment of mania in a patient with Charcot-Marie-Tooth disease : scientific letter




Charcot-Marie-Tooth disease (CMT), also known as Hereditary Sensory Motor Neuropathy (HSMN) is the most common inherited peripheral neuropathy and it can follow autosomal dominant, X-linked, autosomal recessive and even a sporadic inheritance pattern. Very few studies have evaluated psychiatric problems in this disease, but there is a 30% lifetime prevalence of psychiatric disorder in patients with CMT. Depression and phobic disorder are commonly occurring psychiatric comorbidities. After obtaining informed consent, we report the case of a patient with Charcot-Marie-Tooth disease presenting with a manic episode and the treatment thereof with sodium valproate.


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