n Obstetrics and Gynaecology Forum - Pregnancy and coagulation defects : review article




Extracted from text ... REVIEW ARTICLE 21 INTRODUCTION Although fortunately not common, serious bleeding associated with defective coagulation can arise in several obstetric situations. These conditions may result from obstetric complications or be caused by acquired or inherited defects of haemostasis. Such disorders can at times be life threatening to the patient and fetus. To better understand these situations, the physiology and normal alterations during pregnancy will first be discussed. PHYSIOLOGY OF HAEMOSTASIS Normal haemostasis depends upon normal vasculature, platelets, coagulation factors and fibrinolysis. These act together to confine the circulating blood to the vascular bed and arrest bleeding after trauma. Normal coagulation ..


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