n Obstetrics and Gynaecology Forum - Current status of HPV screening : review article

Volume 13, Issue 3
  • ISSN : 1027-9148



Extracted from text ... REVIEW ARTICLE Obstetrics & Gynaecology Forum - August 2003 11 Current status of HPV screening The early protein's function in viral replication and transcription: E1: Required for viral episomal replication E2: Transcriptional regulatory activities and interaction with E1 facilitates its function. E4: Function not well understood. E5: E6: Interact with cellular replication machinery to facilitate viral replication. E7: Viral-transforming activity is also associated with these proteins. Infection is initiated in the nucleus of epithelial cells with circular (episomal) form of the virus. Productive viral infection requires episomal replication. Viral integration into cellular chromosomes disrupts the viral life cycle and ..

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