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Mrs K P, a 29 year old P0G1 who presented at 12 weeks gestation for routine antenatal care. Aneuploidy screen revealed that her composite risk for Down's syndrome using a combination of nuchal translucency (measurement was 1.1mm), nasal bone assessment and biochemistry was low. Her blood group was O positive and screening tests for syphilis, rubella and HIV were negative. There was no family history of genetic or congenital anomalies. The rest of the antenatal care until 22 weeks was uneventful.
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