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Infertility, defined as the inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception, affects approximately 15% of couples, and male factors are the cause in 20%-50% of cases. Despite technological advances, the cause of male infertility is unknown in 25% of these cases. Infertility of unknown origin is classified into idiopathic male infertility and unexplained male infertility according to semen quality.
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