oa Southern African Journal of Anaesthesia and Analgesia - Post-operative neuromuscular function of patients receiving non-depolarising muscle relaxants at Universitas Hospital, Bloemfontein, South Africa : research

Volume 10, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



<I>Objectives</I>: To determine the number of patients whose non-depolarising muscle relaxation is adequately reversed. To define factors that contribute to reversal. <br><I>Design</I>: A cross sectional study. <br><I>Setting</I>: Universitas Hospital recovery room over a 2 month period. <br><I>Subjects</I>: Patients that received non-depolarising muscle relaxants and who gave informed consent. <br><I>Outcome measures</I>: A quantitative train-of-four (TOF) ratio was determined within 5 to 15 minutes after arrival in the recovery room. <br><I>Results</I>: Recovery to TOF>0.9: 57.1% [95% CI 44.8%; 68.9%] patients. Recovery to TOF >0.8: 82.9% [95% CI 72.0%; 90.8%] patients. More patients who received vecuronium recovered to a TOF <0.8 compared with atracurium and cis-atracurium (Fisher's exact test, p=0.0151). <br><I>Conclusions</I>: The muscle relaxation of many patients is not fully reversed in the recovery room, despite a long time lapse since the last drug administration, as well as the administration of neostigmine.

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