oa Southern African Journal of Anaesthesia and Analgesia - Anaphylaxis precipitated by intravenous morphine sulphate : registrar communication

Volume 11, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Morphine is a potent opioid that is used as one of the standard drugs for pain management in perioperative practice. It was first synthesised in 1952 and is the drug against which all other analgesic drugs are compared. It is also one of the most abused drugs worldwide. We present an interesting case of anaphylaxis that was precipitated by a morphine bolus and required aggressive resuscitation. The episode was temporally related to injection and confirmed biochemically by a raised tryptase result.

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