oa Southern African Journal of Anaesthesia and Analgesia - Acute peri-operative beta-blockade in South Africa : 2006 Joint Travel Fellowship

Volume 12, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Extracted from text ... Southern African Journal of Anaesthesia & Analgesia ? March 2006 32 TRAVEL FELLOWSHIP Introduction This paper considers the effect of physiochemical and/or pharmacokinetic properties on the cardioprotective efficacy of acute peri-operative beta-blockade, indications for perioperative beta-blockers and economic viability in South Africa. 1. Is there a preferable peri-operative beta-blocker based on physiochemical and pharmacokinetic properties? a. Physiochemical/ ancillary properties Beta-blockers are protective against sudden arrhythmic death following myocardial infarction (MI).1-2 Although, all beta-blockers are anti-arrhythmic3-5, the betablockers with the greatest efficacy in decreasing sudden arrhythmic death following MI and/or congestive heart failure are lipophilic.6-7 It was proposed that lipophilic ..

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