oa Southern African Journal of Anaesthesia and Analgesia - Effects of inhaled nitric oxide on oxygenation and haemodynamic performance during one-lung ventilation in pigs : laboratory research



<i>Objective:</i> To study the effects of 20 ppm inhaled nitric oxide (iNO) on haemodynamics and systemic oxygenation during one-lung ventilation (OLV) in vivo. <br><i>Design:</i> Prospective animal study with a cross-over design. <br><i>Setting:</i> Animal laboratory of a university hospital. <br><i>Subjects:</i> Eight female pigs. <br><i>Outcome measures:</i> The pigs were anaesthetized, tracheally intubated, and mechanically ventilated. Following placement of femoral arterial and pulmonary artery catheters, a left-sided double-lumen tube (DLT) was placed via tracheotomy. After DLT placement, in each animal OLV was performed during intravenous anaesthesia in a cross-over design with and without iNO (20ppm) in 100% oxygen. After haemodynamic stabilization, haemodynamic measurements and blood gas analyses were made, in addition we measured differential lung perfusion with colored microspheres in three animals. <br><i>Results and Conclusions:</i> iNO did not improve oxygenation nor did iNO reduce pulmonary arterial pressure in our animal model. Mixed venous PvO2 and cardiac output were comparable during the study periods.


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