oa Southern African Journal of Anaesthesia and Analgesia - Postoperative nausea and vomiting : what about substance P antagonism? (or is it just another empty promise? : guest editorial
|Article Title||Postoperative nausea and vomiting : what about substance P antagonism? (or is it just another empty promise? : guest editorial|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Anaesthesia and Analgesia|
|Publication Date||Mar 2007|
|Pages||9 - 10|
Nausea and vomiting are now considered to be ultimately mediated by a central common pathway. Neurokinin 1 (substance P) is the synaptic mediator at this level. Aprepitant is a substance P antagonist at neurokinin 1 receptors and is now available in North America for the prevention of postoperative nausea and vomiting. A basic summary is provided on the physiological and pharmacological basis of this agent.
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