oa Southern African Journal of Anaesthesia and Analgesia - Postoperative nausea and vomiting : what about substance P antagonism? (or is it just another empty promise? : guest editorial

Volume 13, Issue 2
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Nausea and vomiting are now considered to be ultimately mediated by a central common pathway. Neurokinin 1 (substance P) is the synaptic mediator at this level. Aprepitant is a substance P antagonist at neurokinin 1 receptors and is now available in North America for the prevention of postoperative nausea and vomiting. A basic summary is provided on the physiological and pharmacological basis of this agent.

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