oa Southern African Journal of Anaesthesia and Analgesia - Local anaesthetic toxicity : review

Volume 13, Issue 3
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Local anaesthetic toxicity has been known since the introduction of local anaesthetic drugs into anaesthetic practice more than a hundred years ago. The aim of this review is to follow the history of the search for less toxic local anaesthetic drugs, to highlight molecular mechanisms thought to contribute to the clinical phenomenon of toxicity, and to finally discuss novel treatment strategies.

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