oa Southern African Journal of Anaesthesia and Analgesia - Target controlled infusion anaesthesia in children : techniques

Volume 16, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Total intravenous anaesthesia (TIVA) has grown rapidly in popularity over the last two decades in both adult and paediatric anaesthesia. This rapid increase in popularity is in part due to the widespread availability of drugs with favourable pharmacological properties and the development of new concepts in pharmacokinetic modelling, as well as advances in computer technology that have allowed the development of sophisticated anaesthetic delivery systems. This has led to refinements in blood plasma concentration targeting and dosing adjustments. A target controlled infusion (TCI) is an infusion controlled by a real time pharmacokinetic model that achieves a user defined blood or tissue concentration of a drug.

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