oa Southern African Journal of Anaesthesia and Analgesia - Peri-operative diagnosis and treatment of platelet disorders : fluids & bleeding

Volume 16, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



The important role of platelets in the physiology and pathophysiology of haemostasis was acknowledged after the introduction of the cell-based model of coagulation. Hyperactive platelets may contribute to stent thrombosis or disseminated microembolism, leading to organ dysfunction. Platelet inhibition may provoke peri-operativen bleeding, independent of platelet counts. Taken together, on-site diagnosis of actual platelet reactivity may permit rapid and goal-directed therapeutic interventions in patients at risk. There is still no consensus on the appropriate method for measuring platelet function. In this refresher course lecture Platelet Funktion Analyzer PFA-100 and Multiple Electrode Aggregometry MEA will be discussed among other tests for the peri-operative use.

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