oa Southern African Journal of Anaesthesia and Analgesia - Neonatal anaesthesia : paediatric anaesthesia
Safe anaesthesia for neonates is based on understanding their unique physiology and response to medications so as best to provide analgesia and amnesia, depress stress responses, maintain cardiovascular stability, and return them to baseline status. Medications administered by any route have a similarly rapid uptake (alpha phase) followed by the slower elimination phase (beta phase) as adults. However, the duration of these phases is altered by changes in body composition, protein binding, and maturation of organ function.
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