oa Southern African Journal of Anaesthesia and Analgesia - Incretion therapy 2011 : hype or reality? : refresher course
Type 2 diabetes has assumed a pandemic prevalence. In the absence of metabolic control, life expectancy in patients with diabetes is reduced by a mean of 15 years, and morbidity in relation to vascular and neuropathic complications, some three- to fourfold. Adequate metabolic control remains elusive and worldwide, fewer than 40% of patients with diabetes achieve glycaemic targets. This poor outcome is attributable in part to the suboptimal, non-physiological glucose-lowering therapies that are currently available and in routine use. More specifically, effective glucose lowering is currently limited by the concurrent adversities of hypoglycaemia and weight gain.
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