oa Southern African Journal of Anaesthesia and Analgesia - Management strategies in patients with high bleeding and clotting risk : refresher course



Patients undergoing major orthopaedic surgery are at high risk of venous thromboembolism (VTE), with morbid and potentially fatal consequences. Anticoagulant VTE prophylaxis reduces rates of postoperative deep vein thrombosis by up to 60-70% in these patients. Therefore, pharmacological prophylaxis with low-molecular-weight heparins (LMWHs), vitamin K antagonists, or fondaparinux and now new oral anticoagulants, is recommended by current guidelines.


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