oa Southern African Journal of Anaesthesia and Analgesia - Dextropropoxyphene is dead? Long live... : guest editorial

Volume 17, Issue 4
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



On 20 April 2011, the Medicines Control Council (MCC) announced its decision to withdraw all dextropropoxyphene-(DPP-) containing products from the South African market within three months, because of stated safety risks and an insufficiently weighted risk-benefit profile. These risks refer to dose-related cardiac conduction abnormalities associated with QT prolongation, provoked by the main metabolite of DPP, norpropoxyphene.

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