oa Southern African Journal of Anaesthesia and Analgesia - Dextropropoxyphene is dead? Long live... : guest editorial
|Article Title||Dextropropoxyphene is dead? Long live... : guest editorial|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Anaesthesia and Analgesia|
|Publication Date||Jan 2011|
|Pages||276 - 280|
On 20 April 2011, the Medicines Control Council (MCC) announced its decision to withdraw all dextropropoxyphene-(DPP-) containing products from the South African market within three months, because of stated safety risks and an insufficiently weighted risk-benefit profile. These risks refer to dose-related cardiac conduction abnormalities associated with QT prolongation, provoked by the main metabolite of DPP, norpropoxyphene.
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