oa Southern African Journal of Anaesthesia and Analgesia - Ketamine : old dogs, new tricks : refresher course

Volume 19, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Ketamine is one of the oldest intravenous anaesthetic agents that is still in clinical use. Its unique mechanism of action and interaction with a variety of different receptors has sparked renewed interest in its use in a host of alternative clinical settings. This review briefly discusses the pharmacology of ketamine and ketamine's potential use in major depressive illness, opioidinduced acute tolerance and as a potential neuroprotective agent.

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