oa Southern African Journal of Anaesthesia and Analgesia - A comparison of magnesium induced recurarization between neuromuscular block reversal agent in an in vivo rat model. : congress prize abstracts
SSEM Mthembu Medical Research Award
Magnesium recurarization is the sudden reinstatement of neuromuscular impairment upon administration of magnesium sulphate after recovery from neuromuscular block. Magnesium reduces acetylcholine release from the nerve terminal, thus allowing any residual neuromuscular blocking agent to rebind the receptor. Sugammadex is a reversal agent able to bind rocuronium in the plasma, thus promoting the removal of rocuronium from the neuromuscular junction. On the basis of sugammadex's mechanism of action it could prevent or reduce the effect of magnesium recurarization, since a decreased concentration of rocuronium would in effect be available for rebinding the cholinergic receptor. In this study, the magnesium recurarization effect was compared between neuromuscular block reversal with neostigmine, sugammadex and omission of neuromuscular block reversal.
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