1887

oa Southern African Journal of Anaesthesia and Analgesia - Preoperative B-type natriuretic peptides in patients undergoing noncardiac surgery : a cumulative meta-analysis : research

 

Abstract

A plethora of studies have shown elevated preoperative natriuretic peptide measurements to predict postoperative mortality and adverse cardiac events.


The current study aimed to demonstrate this overwhelming association and to show that further studies of this nature are unwarranted.
A cumulative meta-analysis of 28 studies was conducted where the primary outcomes of mortality and adverse cardiac events were associated with elevated preoperative natriuretic peptides.
Cumulative meta-analysis demonstrated an odds ratio trending to a constant of 5.66, with a marked narrowing in the 95% confidence interval.
Further studies aiming only to demonstrate an association between a preoperative natriuretic peptide threshold and the risk of postoperative adverse cardiac events are not justified. Future investigation should focus on the clinical implications of these data and the application of these findings with regard to further investigation, optimisation and appropriate adaptation of perioperative management.

Loading

Article metrics loading...

/content/medsajaa/21/4/EJC176056
2015-01-01
2016-12-08
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error