oa Southern African Journal of Anaesthesia and Analgesia - Anaesthesia associated developmental neurotoxicity (AADN) 2015 : review article

Volume 22, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



The long-term cerebral effects of general anaesthesia at the extremes of age are currently enjoying attention. In children, the concern is that exposure to anaesthesia when less than 4 years of age may cause subsequent learning disabilities and behavioural changes. However, clinical equipoise exists as the available human studies are imperfect and the results of the large-scale multinational trials are not yet available. This structured narrative review summarises the overwhelming amount of information available.

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