oa Southern African Journal of Anaesthesia and Analgesia - The usage and efficacy of a combination analgesic preparation : product survey

Volume 8, Issue 3
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Combination analgesics are frequently prescribed for the treatment of a multitude of conditions. Many of these preparations contain agents with no proven analgesic efficacy. We examined 3059 patients using a new combination agent containing only paracetamol, codeine, and ibuprofen. It appears that despite a wide variation in the administration of the tablet that good pain relief was obtained by the patients. Patient compliance and tolerance of the tablet was good. A small number of adverse events was noted and these were mostly related to the non-steroidal anti-inflammatory component of the tablet. None of the adverse events were considered serious. The tablet was prescribed for a wide range of conditions, most of which involved pain of an inflammatory nature. Most patients indicated that they would use this preparation again if needed.

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