oa Southern African Journal of Anaesthesia and Analgesia - Vasopressin - emerging importance in sepsis : registrar prize

Volume 9, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Extracted from text ... Vasopressin Receptors and Other mechanisms The V1 receptor is present in the vasculature of most organ systems, and, via Gq mediated signalling, causes a rise in Ca++ leading to vasoconstriction. V1 receptor activation also inhibits IL-1 formation, reducing NO production. J Skowno University of Cape Town REGISTRAR PRIZE 54 Left Atrial, Carotid and Aortic Arch baroreceptors sense arterial pressure, and a reduction in MAP triggers the release of Vasopressin. The release is exponential in nature, and AVP levels, normally 3pg/ml can rise to 50-100pg/ml during severe hypotension. Of particular importance is Vasopressin's modulatory effect on the arterial baroreflex itself. ..

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