oa Southern African Journal of Anaesthesia and Analgesia - Endothelium derived factors and pulmonary hypertension : registrar prize

Volume 9, Issue 1
  • ISSN : 2220-1181
  • E-ISSN: 2220-1173



Extracted from text ... REGISTRAR PRIZE 45 Endothelium derived factors and pulmonary hypertension level. Several genetic factors clearly play a role in this disease. It has recently been discovered that primary pulmonary hypertensives lack a receptor for Transforming Growth Factor-??which may allow clonal expansion of endothelial cells.4 Nitric Oxide Previously known as Endothelin Derived Relaxant Factor, Nitric Oxide (NO) is a potent vasodilator of pulmonary and systemic blood vessels. Pulmonary selectivity relies on inhaled NO being delivered directly to ventilated pulmonary vasculature with rapid plasma inactivation before reaching the systemic circulation. Inhaled NO has been used for persistent pulmonary hypertension of the newborn, ..

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